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Adaani E Frost Selected Research

sitaxsentan

12/2015Endothelin-1 Pathway Polymorphisms and Outcomes in Pulmonary Arterial Hypertension.
1/2009Ambrisentan therapy in patients with pulmonary arterial hypertension who discontinued bosentan or sitaxsentan due to liver function test abnormalities.
11/2007Selective endothelin A receptor antagonism with sitaxsentan for pulmonary arterial hypertension associated with connective tissue disease.
6/2005The 6-min walk test (6MW) as an efficacy endpoint in pulmonary arterial hypertension clinical trials: demonstration of a ceiling effect.

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Adaani E Frost Research Topics

Disease

22Pulmonary Arterial Hypertension
12/2019 - 09/2004
11Pulmonary Hypertension
01/2022 - 09/2004
3Connective Tissue Diseases (Connective Tissue Disease)
07/2017 - 11/2007
3Dyspnea (Shortness of Breath)
12/2012 - 10/2008
3Congenital Heart Defects (Congenital Heart Defect)
10/2008 - 04/2005
2Disease Progression
01/2019 - 12/2018
1Vasoplegia
01/2022
1Pulmonary Veno-Occlusive Disease (Veno Occlusive Disease, Pulmonary)
01/2021
1Pregnancy Complications
01/2021
1Left Ventricular Dysfunction
12/2019
1Hypoxia (Hypoxemia)
01/2018
1Portal Hypertension
10/2016
1Heart Failure
10/2016
1Pericardial Effusion
03/2015
1Chronic Renal Insufficiency
02/2015
1Subdural Hematoma (Subdural Hemorrhage)
03/2013
1Fatigue
12/2012
1Dyspepsia (Indigestion)
10/2008
1Pain (Aches)
10/2008
1Headache (Headaches)
10/2008
1Nausea
10/2008
1Infections
08/2005
1Vascular Diseases (Vascular Disease)
08/2005
1Lymphoproliferative Disorders (Lymphoproliferative Disorder)
06/2005
1Bronchiolitis Obliterans Syndrome
06/2005
1Atrial Heart Septal Defects (Atrial Septal Defect)
04/2005
1Hyalohyphomycosis
05/2002

Drug/Important Bio-Agent (IBA)

9ambrisentanFDA Link
12/2019 - 08/2005
7Tadalafil (Cialis)FDA Link
12/2019 - 08/2015
4sitaxsentanIBA
12/2015 - 06/2005
4Epoprostenol (Prostacyclin)FDA LinkGeneric
02/2015 - 09/2004
2Biomarkers (Surrogate Marker)IBA
01/2018 - 01/2018
2Brain Natriuretic Peptide (Natrecor)FDA Link
01/2018 - 03/2015
2Imatinib Mesylate (Gleevec)FDA Link
11/2015 - 03/2013
2Endothelin Receptor AntagonistsIBA
12/2012 - 09/2004
2treprostinilFDA Link
12/2012 - 09/2004
2Bosentan (Tracleer)FDA Link
01/2009 - 09/2004
2Endothelin A ReceptorIBA
11/2007 - 06/2005
1Illicit Drugs (Recreational Drugs)IBA
01/2021
1Oral ContraceptivesIBA
01/2021
17-(N-(3-aminopropyl)amino)heptan-2-oneIBA
01/2021
1Hormones (Hormone)IBA
04/2019
1Oxygen (Dioxygen)IBA
01/2018
1Indicators and Reagents (Reagents)IBA
04/2017
1Endothelin-1 (Endothelin 1)IBA
12/2015
1Protein Kinases (Protein Kinase)IBA
11/2015
1Platelet-Derived Growth FactorIBA
03/2013
1Phosphodiesterase 5 InhibitorsIBA
12/2012
1Transaminases (Aminotransferases)IBA
01/2009
1Pharmaceutical PreparationsIBA
01/2009
1Sildenafil Citrate (Viagra)FDA Link
10/2008
1Endothelin Receptors (Endothelin Receptor)IBA
11/2007
1CollagenIBA
08/2005
1Endothelins (Endothelin)IBA
08/2005
1Vasodilator Agents (Vasodilators)IBA
04/2005
1Prostaglandins IIBA
09/2004
1Amphotericin B (Amphotericin)FDA LinkGeneric
05/2002

Therapy/Procedure

20Therapeutics
12/2019 - 04/2005
2Kidney Transplantation
01/2022 - 12/2020
2Heart-Assist Devices
01/2022 - 06/2009
1Cardiopulmonary Bypass (Heart-Lung Bypass)
01/2022
1Liver Transplantation
10/2016
1Organ Transplantation
10/2016
1Renal Dialysis (Hemodialysis)
10/2010
1Endarterectomy (Thromboendarterectomy)
06/2009
1Drug Tapering
01/2009
1Aftercare (After-Treatment)
04/2005